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TrueCrypt encrypts your hard disk, making it the safest place on earth! This software is a free open-source disk encryption software for Windows Vista/XP , Mac OS X, and Linux. With a few easy step you can secure your computer and, at the same time, go on working on it. Its features include:

• Creates a virtual encrypted disk within a file and mounts it as a real disk.
• Encrypts an entire hard disk partition or a storage device such as USB flash drive.
• Ability to encrypt a system partition/drive (i.e. a partition/drive where Windows is installed) with pre-boot authentication (anyone who wants to gain access and use the system, read and write files, etc., needs to enter the correct password each time before the system starts). For more information, see the chapter System Encryption in the documentation. (Windows Vista/XP/2003)

The list of its feature continues and it is really impressive. Read it here and download the software here.